Built in 1872 and located at the Osage Mission, this building was the infirmary for the mission under the watchful eye of the Jesuits and the Sisters of Loretto. In 1912 it was moved to its present location to be used as a residence. A wood-frame house, it has a dormered, mansard roof and was constructed in the Second Empire style. The old infirmary most recently operated as a bed and breakfast. (NRHP)